:root {
  --paper: #f4f0e7;
  --paper-deep: #e9e1d3;
  --ink: #171512;
  --muted: #6d675d;
  --red: #a9151e;
  --red-dark: #711017;
  --red-bright: #c3232d;
  --gold: #aa8553;
  --line: rgba(23, 21, 18, 0.15);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: "Noto Serif SC", "Songti SC", "SimSun", Georgia, serif;
  -webkit-font-smoothing: antialiased;
}
a { color: inherit; text-decoration: none; }
img { display: block; max-width: 100%; }
button, input, textarea { font: inherit; }
::selection { color: #fff; background: var(--red); }

.site-header {
  position: absolute;
  z-index: 20;
  top: 0;
  left: 0;
  width: 100%;
  height: 96px;
  padding: 0 clamp(24px, 5vw, 80px);
  display: grid;
  grid-template-columns: minmax(210px, 1fr) auto minmax(150px, 1fr);
  align-items: center;
  border-bottom: 1px solid rgba(255,255,255,.18);
  color: #fff;
}
.brand img { width: clamp(220px, 20vw, 300px); filter: brightness(0) invert(1); }
.desktop-nav { display: flex; align-items: center; gap: clamp(24px, 3vw, 48px); font-family: "Microsoft YaHei", sans-serif; font-size: 14px; letter-spacing: .08em; }
.desktop-nav a, .footer-nav a { position: relative; opacity: .78; transition: opacity .25s ease; }
.desktop-nav a::after, .footer-nav a::after { content: ""; position: absolute; left: 0; bottom: -9px; width: 0; height: 1px; background: currentColor; transition: width .25s ease; }
.desktop-nav a:hover, .desktop-nav a:focus-visible, .footer-nav a:hover, .footer-nav a:focus-visible { opacity: 1; }
.desktop-nav a:hover::after, .desktop-nav a:focus-visible::after, .footer-nav a:hover::after, .footer-nav a:focus-visible::after { width: 100%; }
.header-cta { justify-self: end; min-width: 124px; padding: 13px 20px; text-align: center; border: 1px solid rgba(255,255,255,.58); font-family: "Microsoft YaHei", sans-serif; font-size: 14px; letter-spacing: .12em; transition: .25s ease; }
.header-cta:hover { color: var(--red-dark); background: #fff; }
.mobile-menu { display: none; justify-self: end; position: relative; font-family: "Microsoft YaHei", sans-serif; }
.mobile-menu summary { cursor: pointer; list-style: none; border: 1px solid rgba(255,255,255,.5); padding: 9px 14px; }
.mobile-menu summary::-webkit-details-marker { display: none; }
.mobile-menu nav { position: absolute; right: 0; top: 46px; width: 180px; display: grid; padding: 12px; color: var(--ink); background: #fff; box-shadow: 0 20px 50px rgba(0,0,0,.25); }
.mobile-menu nav a { padding: 12px; border-bottom: 1px solid var(--line); }

.hero {
  position: relative;
  min-height: 860px;
  height: min(1000px, 100vh);
  overflow: hidden;
  display: grid;
  grid-template-columns: 56% 44%;
  color: #fff;
  background:
    radial-gradient(circle at 73% 44%, rgba(212,73,71,.3), transparent 26%),
    linear-gradient(110deg, #651014 0%, #8e1119 49%, #5b090d 100%);
}
.hero::before {
  content: ""; position: absolute; inset: 0;
  background-image: repeating-linear-gradient(90deg, transparent 0, transparent 119px, rgba(255,255,255,.025) 120px);
  pointer-events: none;
}
.hero::after {
  content: ""; position: absolute; left: 56%; top: 0; bottom: 0; width: 1px; background: rgba(255,255,255,.14);
}
.hero-grain { position: absolute; inset: 0; opacity: .12; background-image: url("data:image/svg+xml,%3Csvg viewBox='0 0 180 180' xmlns='http://www.w3.org/2000/svg'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='.9' numOctaves='3' stitchTiles='stitch'/%3E%3C/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)' opacity='.33'/%3E%3C/svg%3E"); pointer-events: none; }
.hero-copy { position: relative; z-index: 2; padding: 190px 7vw 72px 9vw; align-self: center; }
.eyebrow { display: flex; align-items: center; gap: 14px; margin: 0 0 30px; color: #e9cfb0; font-family: "Microsoft YaHei", sans-serif; font-size: 14px; letter-spacing: .35em; }
.eyebrow span { width: 32px; height: 1px; background: #d5ae7d; }
.hero h1 { margin: 0; font-size: clamp(56px, 5.2vw, 86px); font-weight: 500; line-height: 1.24; letter-spacing: .06em; }
.hero h1 em { display: block; color: #ead9be; font-style: normal; }
.hero-lead { max-width: 650px; margin: 36px 0 0; color: rgba(255,255,255,.75); font-family: "Microsoft YaHei", sans-serif; font-size: 17px; line-height: 2; letter-spacing: .06em; }
.hero-actions { display: flex; gap: 16px; margin-top: 42px; }
.button { display: inline-flex; align-items: center; justify-content: center; gap: 28px; min-height: 52px; padding: 0 26px; font-family: "Microsoft YaHei", sans-serif; font-size: 14px; letter-spacing: .1em; transition: transform .2s ease, color .2s ease, background .2s ease; }
.button:hover { transform: translateY(-2px); }
.button-primary { color: var(--red-dark); background: #f3eadb; }
.button-primary:hover { background: #fff; }
.button-ghost { border: 1px solid rgba(255,255,255,.42); color: #fff; }
.button-ghost:hover { background: rgba(255,255,255,.1); }
.hero-principles { display: flex; gap: clamp(26px, 4vw, 64px); margin-top: 62px; padding-top: 26px; border-top: 1px solid rgba(255,255,255,.14); }
.hero-principles div { display: grid; gap: 6px; }
.hero-principles b { font-size: 22px; font-weight: 500; letter-spacing: .2em; }
.hero-principles span { color: rgba(255,255,255,.5); font-family: "Microsoft YaHei", sans-serif; font-size: 11px; letter-spacing: .12em; }
.hero-visual { position: relative; z-index: 2; align-self: center; justify-self: center; width: 100%; display: grid; place-items: center; padding-top: 72px; }
.seal-frame { position: relative; width: min(30vw, 420px); aspect-ratio: 1; display: grid; place-items: center; border: 1px solid rgba(239,216,183,.32); transform: rotate(45deg); }
.seal-frame::before, .seal-frame::after { content: ""; position: absolute; inset: 18px; border: 1px solid rgba(239,216,183,.16); }
.seal-frame::after { inset: 42px; border-style: dashed; }
.seal-frame img { width: 78%; transform: rotate(-45deg); filter: brightness(0) invert(1); opacity: .94; }
.corner { position: absolute; width: 18px; height: 18px; border-color: #d5ae7d; border-style: solid; }
.corner-tl { top: -1px; left: -1px; border-width: 2px 0 0 2px; }.corner-tr { top: -1px; right: -1px; border-width: 2px 2px 0 0; }.corner-bl { bottom: -1px; left: -1px; border-width: 0 0 2px 2px; }.corner-br { bottom: -1px; right: -1px; border-width: 0 2px 2px 0; }
.seal-halo { position: absolute; border-radius: 50%; border: 1px solid rgba(255,255,255,.09); }
.halo-one { width: 520px; height: 520px; }.halo-two { width: 680px; height: 680px; border-style: dashed; }
.hero-visual p { margin: 82px 0 0; color: #dab994; font-family: "Microsoft YaHei", sans-serif; font-size: 12px; letter-spacing: .5em; }
.hero-side-note { position: absolute; z-index: 2; right: 26px; bottom: 44px; writing-mode: vertical-rl; color: rgba(255,255,255,.26); font-family: Arial, sans-serif; font-size: 10px; letter-spacing: .35em; }

.section { padding: 120px clamp(24px, 9vw, 150px); }
.section-kicker { display: flex; align-items: center; gap: 18px; color: #8e877d; font-family: Arial, sans-serif; font-size: 10px; letter-spacing: .28em; }
.section-kicker::after { content: ""; flex: 1; height: 1px; background: var(--line); }
.section-kicker span { width: 32px; height: 32px; display: grid; place-items: center; color: var(--red); border: 1px solid rgba(169,21,30,.35); font-family: "Songti SC", serif; font-size: 15px; letter-spacing: 0; }
.intro { background: var(--paper); }
.intro-grid { display: grid; grid-template-columns: .82fr 1.18fr; gap: 10vw; padding-top: 76px; }
.overline { margin: 0 0 20px; color: var(--red); font-family: "Microsoft YaHei", sans-serif; font-size: 12px; letter-spacing: .28em; }
.overline.light { color: #d7b58c; }
.intro h2, .method h2, .contact h2 { margin: 0; font-size: clamp(46px, 5vw, 76px); font-weight: 500; line-height: 1.36; letter-spacing: .08em; }
.intro-copy { max-width: 680px; }
.large-copy { margin: 0 0 26px !important; color: #2f2923 !important; font-size: clamp(24px, 2.2vw, 34px) !important; font-family: "Songti SC", serif !important; line-height: 1.7 !important; }
.intro-copy > p { margin: 0; color: var(--muted); font-family: "Microsoft YaHei", sans-serif; font-size: 16px; line-height: 2.05; }
.quote-line { display: flex; align-items: center; gap: 22px; margin-top: 50px; padding-top: 30px; border-top: 1px solid var(--line); }
.quote-line > span { width: 62px; height: 62px; display: grid; place-items: center; flex: 0 0 auto; color: #fff; background: var(--red); font-size: 32px; }
.quote-line p { margin: 0; color: #4a4238; font-size: 15px; line-height: 1.8; letter-spacing: .13em; }

.research { color: #fff; background: #191713; }
.section-heading { display: grid; grid-template-columns: 1fr .7fr; align-items: end; gap: 80px; }
.section-heading h2 { margin: 0; font-size: clamp(46px, 5vw, 76px); font-weight: 500; line-height: 1.35; letter-spacing: .08em; }
.section-heading > p { margin: 0 0 12px; color: rgba(255,255,255,.52); font-family: "Microsoft YaHei", sans-serif; font-size: 15px; line-height: 2; }
.research-grid { display: grid; grid-template-columns: repeat(4, 1fr); margin-top: 70px; border-top: 1px solid rgba(255,255,255,.15); border-left: 1px solid rgba(255,255,255,.15); }
.research-card { position: relative; min-height: 380px; overflow: hidden; padding: 30px 28px; border-right: 1px solid rgba(255,255,255,.15); border-bottom: 1px solid rgba(255,255,255,.15); transition: background .3s ease, transform .3s ease; }
.research-card:hover { z-index: 2; background: var(--red); transform: translateY(-8px); }
.card-top { display: flex; justify-content: space-between; align-items: center; }
.card-top > span { color: #d7b58c; font-family: Georgia, serif; font-size: 14px; }
.card-top i { color: rgba(255,255,255,.42); font-family: "Microsoft YaHei", sans-serif; font-size: 10px; font-style: normal; letter-spacing: .12em; }
.research-card h3 { max-width: 220px; margin: 76px 0 20px; font-size: 25px; font-weight: 500; line-height: 1.5; letter-spacing: .08em; }
.research-card > p { position: relative; z-index: 1; margin: 0; color: rgba(255,255,255,.52); font-family: "Microsoft YaHei", sans-serif; font-size: 14px; line-height: 1.85; }
.research-card:hover > p, .research-card:hover .card-top i { color: rgba(255,255,255,.75); }
.card-mark { position: absolute; right: -10px; bottom: -52px; color: rgba(255,255,255,.025); font-size: 190px; line-height: 1; }

.method { background: #eee7db; }
.method-layout { display: grid; grid-template-columns: .75fr 1.25fr; gap: 10vw; margin-top: 70px; }
.method-title > p:last-child { max-width: 420px; margin-top: 32px; color: var(--muted); font-family: "Microsoft YaHei", sans-serif; line-height: 2; }
.pathway { margin: 0; padding: 0; list-style: none; border-top: 1px solid #c9bdac; }
.pathway li { display: grid; grid-template-columns: 58px 1fr auto; align-items: center; gap: 20px; min-height: 124px; border-bottom: 1px solid #c9bdac; transition: padding .25s ease, background .25s ease; }
.pathway li:hover { padding: 0 18px; background: rgba(255,255,255,.44); }
.path-number { color: var(--red); font-family: Georgia, serif; font-size: 12px; }
.pathway h3 { margin: 0 0 9px; font-size: 24px; font-weight: 500; letter-spacing: .16em; }
.pathway p { margin: 0; color: var(--muted); font-family: "Microsoft YaHei", sans-serif; font-size: 13px; line-height: 1.7; }
.path-arrow { color: #8c7e6b; font-size: 18px; }

.cooperate { position: relative; min-height: 670px; overflow: hidden; display: grid; grid-template-columns: 1.2fr .8fr; color: #fff; background: var(--red-dark); }
.cooperate::before { content: ""; position: absolute; inset: 0; background: linear-gradient(90deg, transparent 49.9%, rgba(255,255,255,.1) 50%, transparent 50.1%); }
.cooperate-inner { position: relative; z-index: 2; padding: 110px 7vw 100px 9vw; }
.cooperate h2 { margin: 0; font-size: clamp(48px, 5.4vw, 82px); font-weight: 500; line-height: 1.32; letter-spacing: .08em; }
.cooperate-lead { max-width: 680px; margin: 30px 0 0; color: rgba(255,255,255,.67); font-family: "Microsoft YaHei", sans-serif; font-size: 15px; line-height: 2; }
.cooperate-types { display: flex; flex-wrap: wrap; gap: 10px; margin: 34px 0 42px; }
.cooperate-types span { padding: 9px 16px; border: 1px solid rgba(255,255,255,.22); color: rgba(255,255,255,.72); font-family: "Microsoft YaHei", sans-serif; font-size: 12px; letter-spacing: .08em; }
.button-paper { color: var(--red-dark); background: #efe6d8; }
.cooperate-seal { position: relative; display: grid; place-items: center; }
.cooperate-seal::before { content: ""; position: absolute; width: min(36vw, 500px); aspect-ratio: 1; border: 1px solid rgba(255,255,255,.17); border-radius: 50%; }
.cooperate-seal::after { content: "启 · 生 · 堂 · 中 · 医 · 医 · 学 · 研 · 究"; position: absolute; width: min(42vw, 580px); aspect-ratio: 1; display: grid; place-items: start center; padding-top: 12px; border: 1px dashed rgba(255,255,255,.1); border-radius: 50%; color: rgba(255,255,255,.28); font-size: 12px; letter-spacing: .8em; }
.cooperate-seal img { position: relative; z-index: 1; width: min(25vw, 340px); filter: brightness(0) invert(1); opacity: .86; }

.contact { display: grid; grid-template-columns: .9fr 1.1fr; gap: 10vw; background: var(--paper); }
.contact-main > p:not(.overline) { max-width: 430px; margin: 28px 0 34px; color: var(--muted); font-family: "Microsoft YaHei", sans-serif; line-height: 1.9; }
.contact .button-primary { color: #fff; background: var(--red); }
.contact .button-primary:hover { background: var(--red-dark); }
.contact-details { border-top: 1px solid var(--line); }
.contact-details > div { display: grid; grid-template-columns: 120px 1fr; gap: 12px 28px; padding: 29px 0; border-bottom: 1px solid var(--line); }
.contact-details span { color: #8a8175; font-family: "Microsoft YaHei", sans-serif; font-size: 12px; letter-spacing: .12em; }
.contact-details strong { font-size: 19px; font-weight: 500; letter-spacing: .05em; }
.contact-details small { grid-column: 2; color: #9a9287; font-family: "Microsoft YaHei", sans-serif; font-size: 11px; }

footer { padding: 64px clamp(24px, 7vw, 110px) 26px; color: rgba(255,255,255,.72); background: #15130f; }
.footer-brand { display: flex; align-items: center; justify-content: space-between; gap: 24px; padding-bottom: 44px; border-bottom: 1px solid rgba(255,255,255,.1); }
.footer-brand img { width: 270px; filter: brightness(0) invert(1); opacity: .88; }
.footer-brand p { margin: 0; font-size: 15px; letter-spacing: .13em; }
.footer-nav { display: flex; justify-content: center; gap: 54px; padding: 30px 0; font-family: "Microsoft YaHei", sans-serif; font-size: 12px; }
.footer-bottom { display: flex; justify-content: space-between; gap: 40px; padding-top: 24px; border-top: 1px solid rgba(255,255,255,.1); color: rgba(255,255,255,.34); font-family: "Microsoft YaHei", sans-serif; font-size: 10px; line-height: 1.7; }
.footer-bottom p { margin: 0; }

@media (max-width: 1100px) {
  .site-header { grid-template-columns: 1fr auto; }
  .desktop-nav, .header-cta { display: none; }
  .mobile-menu { display: block; }
  .hero { grid-template-columns: 62% 38%; }
  .hero-copy { padding-left: 7vw; }
  .hero-visual { transform: scale(.82); }
  .research-grid { grid-template-columns: repeat(2, 1fr); }
  .method-layout { gap: 6vw; }
}

@media (max-width: 760px) {
  .site-header { height: 76px; padding: 0 20px; }
  .brand img { width: 205px; }
  .hero { height: auto; min-height: 850px; display: block; }
  .hero::after, .hero-side-note { display: none; }
  .hero-copy { padding: 140px 24px 70px; }
  .hero h1 { font-size: clamp(44px, 12vw, 62px); }
  .hero-lead { font-size: 14px; line-height: 1.9; }
  .hero-actions { flex-direction: column; align-items: stretch; }
  .hero-principles { gap: 18px; justify-content: space-between; }
  .hero-principles span { font-size: 9px; }
  .hero-visual { position: absolute; right: -120px; bottom: -20px; opacity: .15; transform: scale(.75); }
  .section { padding: 80px 24px; }
  .section-kicker { margin-bottom: 0; }
  .intro-grid, .section-heading, .method-layout, .contact { grid-template-columns: 1fr; }
  .intro-grid { gap: 42px; padding-top: 54px; }
  .intro h2, .method h2, .contact h2 { font-size: 47px; }
  .section-heading { gap: 30px; }
  .research-grid { grid-template-columns: 1fr; margin-top: 50px; }
  .research-card { min-height: 310px; }
  .research-card h3 { margin-top: 52px; }
  .method-layout { gap: 48px; margin-top: 54px; }
  .pathway li { grid-template-columns: 38px 1fr auto; }
  .cooperate { min-height: auto; display: block; }
  .cooperate-inner { padding: 80px 24px 90px; }
  .cooperate h2 { font-size: 49px; }
  .cooperate-seal { position: absolute; right: -170px; bottom: -170px; opacity: .22; }
  .contact { gap: 56px; }
  .contact-details > div { grid-template-columns: 92px 1fr; }
  .footer-brand, .footer-bottom { align-items: flex-start; flex-direction: column; }
  .footer-brand img { width: 230px; }
  .footer-nav { justify-content: flex-start; flex-wrap: wrap; gap: 20px 32px; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition-duration: .01ms !important; }
}